Free-Wilson analysis of the inhibitory effect of 4-substituted benzamidines on thrombin, plasmin and trypsin
Labes, D.; Hagen, V.
Die Pharmazie 34(9): 554-556
1979
ISSN/ISBN: 0031-7144 PMID: 161622 Document Number: 144281
Using the Fujita-Ban model, the authors studied the quantitative structure-inhibitory activity relationships of a series of 4-amidinophenyl compounds with regard to thrombin, plasmin and trypsin. A satisfactory specification of the inhibitory activities was obtained from activity increments of molecular segments.
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