New 2,4-dibromo-6- (N-cyclohexyl-N-methyl) -aminomethylanilides of derivatives of cysteine and cystine with expectorant activity
Nardi, D.; Motta, G.; Tajana, A.; Catto, A.; Cazzulani, P.; Leonardi, A.
Il Farmaco; Edizione Scientifica 40(2): 108-119
1985
ISSN/ISBN: 0430-0920 PMID: 3996580 Document Number: 248286
New 2,4-dibromo-6-(N-cyclohexyl-N-methyl)aminomethylanilides of N-acetylcysteine and N-acetyl-S-carboxymethylcisteine derivatives, N-benzyloxycarbonylcysteine and N,N'-bisbenzyloxycarbonylcystine were synthesized. The compounds were tested for the expectorant activity in rabbit and mouse. N,N'-Bisbenzyloxycarbonylcystin-bis [2,4-dibromo-6-(N-cyclohexyl-N-methyl)aminomethyl]anilide (XIX) was selected for further investigations.
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